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Fioricet contains a combination of acetaminophen, butalbital, and caffeine. Acetaminophen is a pain reliever and fever reducer. Butalbital is in a group of drugs called barbiturates. It relaxes muscle contractions involved in a tension headache. Caffeine is a central nervous system stimulant. It relaxes muscle contractions in blood vessels to improve blood flow.
Fioricet is used to treat tension headaches that are caused by muscle contractions.
Tramadol is a narcotic-like pain reliever. Tramadol is used to treat moderate to severe pain. Tramadol extended-release is used to treat moderate to severe chronic pain when treatment is needed around the clock.
Soma is a muscle relaxer that works by blocking pain sensations between the nerves and the brain. Soma is used together with rest and physical therapy to treat injuries and other painful musculoskeletal conditions.
Tramadol may be habit-forming and should be used only by the person it was prescribed for. Tramadol should never be given to another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it. Tramadol can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Do not stop using tramadol suddenly, or you could have unpleasant withdrawal symptoms such as anxiety, sweating, nausea, diarrhea, tremors, chills, hallucinations, trouble sleeping, or breathing problems. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication.
Do not crush the tramadol tablet. This medicine is for oral (by mouth) use only. Powder from a crushed tablet should not be inhaled or diluted with liquid and injected into the body. Using this medicine by inhalation or injection can cause life-threatening side effects, overdose, or death.
Tramadol side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using tramadol and call your doctor at once if you have any of these serious side effects:
-
agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting;
-
seizure (convulsions);
-
a red, blistering, peeling skin rash; or
-
shallow breathing, weak pulse.
Less serious side effects may include:
-
dizziness, drowsiness, weakness;
-
nausea, vomiting, constipation, loss of appetite;
-
blurred vision;
-
flushing (redness, warmth, or tingly feeling); or
-
sleep problems (insomnia).
Tramadol may be habit-forming and should be used only by the person it was prescribed for. Tramadol should never be given to another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it. Tramadol can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Do not stop using tramadol suddenly, or you could have unpleasant withdrawal symptoms such as anxiety, sweating, nausea, diarrhea, tremors, chills, hallucinations, trouble sleeping, or breathing problems. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication.
Do not crush the tramadol tablet. This medicine is for oral (by mouth) use only. Powder from a crushed tablet should not be inhaled or diluted with liquid and injected into the body. Using this medicine by inhalation or injection can cause life-threatening side effects, overdose, or death.
Tramadol is a synthetic stripped-down piperidine-analog of the phenanthrene alkaloid codeine and, as such, is an opioid and also a prodrug (codeine is metabolized to morphine, tramadol is converted to M-1 aka O-desmethyltramadol). Opioids are chemical compounds which act upon one or more of the human opiate receptors (the euphoria, addictive nature and respiratory depression are mainly caused by the Mu(¦Ì) 1 and 2 receptor. The opioid agonistic effect of tramadol and its major metabolite(s) are almost exclusively mediated by the substance's action at the ¦Ì-opioid receptor. This characteristic distinguishes tramadol from many other substances (including morphine) of the opioid drug class, which generally do not possess tramadol's degree of subtype selectivity.
ULTRAM? (tramadol hydrochloride) tablets is a centrally acting analgesic. The chemical name for tramadol hydrochloride is (¡À)cis-2-[(dimethylamino)methyl]-1-(3methoxyphenyl) cyclohexanol hydrochloride. Its structural formula is:
The molecular weight of tramadol hydrochloride is 299.8. Tramadol hydrochloride is a white, bitter, crystalline and odorless powder. It is readily soluble in water and ethanol and has a pKa of 9.41. The n-octanol/water log partition coefficient (logP) is 1.35 at pH 7. ULTRAM? tablets contain 50 mg of tramadol hydrochloride and are white in color. Inactive ingredients in the tablet are pregelatinized corn starch, modified starch (corn), hypromellose, lactose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, sodium starch glycolate, titanium dioxide and carnauba wax.
Respiratory depression and constipation are less common with tramadol and less pronounced than with other opioids. However, respiratory depression can occur, in particular, after overdose and with impaired renal function. Unlike other opioids, tramadol is not usually associated with the development of tolerance, physical dependence or psychological addiction.
In clinical trials the most common adverse reactions, in decreasing frequency, were nausea, dizziness, drowsiness, tiredness, fatigue, sweating, vomiting, dry mouth and postural hypotension. Tramadol may possibly increase the risk of seizures in those with a history of epilepsy or those on medication, which lowers the seizure threshold, but it appears that tramadol does not induce idiopathic seizures except at very high doses. Tramadol is contraindicated in users of MAO inhibitors as a safety precaution and, because of the risk of serotonin syndrome, should be used with caution in combination with SSRIs.
Tramadol side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using tramadol and call your doctor at once if you have any of these serious side effects:
- agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting;
- seizure (convulsions);
- a red, blistering, peeling skin rash; or
- shallow breathing, weak pulse.
Less serious side effects may include:
- dizziness, drowsiness, weakness;
- nausea, vomiting, constipation, loss of appetite;
- blurred vision;
- flushing (redness, warmth, or tingly feeling); or
- sleep problems (insomnia).
Proven efficacy in a broad range of painful conditions
Tramadol has a dose-dependent efficacy that lies between that of codeine and morphine, with a parenteral potency comparable to that of pethidine, i.e. about 10-20% of the gold standard morphine. Oral bioavailability is high (85-100%) and permits easy conversion from the oral to the parenteral route and visa versa. Surprisingly, the efficacy of tramadol is not associated with the usual serious opioid side effects which can often be dose-limiting. Furthermore, unlike nonsteroidal anti-inflammatory drugs, tramadol has no serious adverse gastrointestinal effects, such as gastrointestinal bleeding. Numerous clinical trials have proven its efficacy and safety over a broad range of painful conditions, both acute and chronic; however, in severe pain morphine may be superior to tramadol. It is this combination of safety with good efficacy that has made tramadol a unique addition to the analgesic armamentarium.
Dual mechanism may explain improved side effect profile
The novel way in which tramadol provides analgesia with fewer side effects may be explained by its dual mechanism of action, opioid and monoaminergic. Its major metabolite O-desmethyl tramadol (M1) has a weak affinity at ¦Ì-opioid receptors as an agonist. The monoaminergic activity comes through the two stereoisomers of tramadol itself, which act synergistically on serotonergic and noradrenergic mechanisms of pain transmission. More specifically, tramadol enhances spinal pain inhibitory pathways by inhibiting neuronal re-uptake of serotonin (5-HT) and noradrenaline (NA), and stimulating 5-HT release. This added monoaminergic component possibly allows tramadol¡¯s efficacy to stretch over a wider range of painful pathologies than other opioids.
What other drugs will affect tramadol?
You may be more likely to have a seizure (convulsions) if you take tramadol while you are using certain other medicines. Do not take tramadol without telling your doctor if you also use any of the following medications:
- an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), or selegiline (Eldepryl, Emsam); or
- an antidepressant such as amitriptyline (Elavil), citalopram (Celexa), clomipramine (Anafranil), desipramine (Norpramin), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), imipramine (Tofranil), nortriptyline (Pamelor); paroxetine (Paxil), or sertraline (Zoloft).
Before taking tramadol, tell your doctor if you also use:
- carbamazepine (Tegretol);
- warfarin (Coumadin);
- digoxin (Lanoxin, Lanoxicaps);
- ketoconazole (Nizoral);
- erythromycin (E-Mycin, E.E.S., Ery-Tab);
- rifampin (Rifadin, Rimactane, Rifater);
- St. John's wort;
- quinidine (Quinaglute, Quinadex, Cardioquin, Quinora); or
- drugs that make you sleepy (such as cold medicine, other pain medications, muscle relaxants, and medicine for seizures, depression or anxiety).
This list is not complete and there may be other drugs that can interact with tramadol. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
HOW SUPPLIED
ULTRAM? (tramadol hydrochloride) Tablets - 50 mg are white, capsule-shaped, coated tablet imprinted ¡°ULTRAM¡± on one side and ¡°06 59¡± on the scored side.
Bottles of 100 tablets: NDC 0045-0659-60
Dispense in a tight container. Store at 25¡ãC (77¡ãF); excursions permitted to 15 -30¡ãC (59 ¨C 86¡ãF).
For More Information, please check Buy Fioricet, Buy Tramadol, Buy Carisoprodol Online Resources.
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